Who says can't you remove USERS ?
As long it is not in here:
SQL> select * from database_Properties where property_name like '%TABLE%'
2 @pr
==============================
PROPERTY_NAME : DEFAULT_PERMANENT_TABLESPACE
PROPERTY_VALUE : USERS
DESCRIPTION : Name of default permanent tablespace
==============================
PROPERTY_NAME : DEFAULT_TEMP_TABLESPACE
PROPERTY_VALUE : TEMP
DESCRIPTION : Name of default temporary tablespace
PL/SQL procedure successfully completed.
then its just like any other tablespace