The thing to remember is that a SQL profile is essentially an extended set of hints to help the optimizer get better row estimates. Unlike baselines, they don't lock the statement to a specific plan.

Over time your data will change. If this leads to operations returning a signfiicantly different number of rows than the profile suggests, you may get a slower plan.

For example, say your company starts selling a set of new products which bring in many new customers. So the distribution and relationship between these values change notably. In which case the cardinality tweaks in the profile may no longer be accurate.

Or maybe some world-changing event happens (see: 2020), which cause a huge shift in buying patterns. Again, the profile may now give misleading estimates.

Ultimately as long as the statement the SQL profile is on meets your performance targets, you're fine. If the query takes too long, refreshing the profile (may) help the optimizer find a faster plan.